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Eruption caused by drug

MedGen UID:
8328
•Concept ID:
C0011609
•
Pathologic Function
Synonyms: Dermatitis Medicamentosa; Dermatitis, Adverse Drug Reaction; Drug Eruption; Drug Eruptions; Eruption, Drug; Eruptions, Drug
SNOMED CT: Drug-induced rash (28926001); Drug-induced dermatosis (403675008); Eruption caused by drug (28926001); Dermatitis medicamentosa (28926001); Drug rash (28926001); Drug eruption (28926001)

Definition

An eruption in the skin due to exposure to a pharmacologic substance. [from NCI]

Professional guidelines

PubMed

Acute Generalized Exanthematous Pustulosis: Clinical Features, Differential Diagnosis, and Management.
Parisi R, Shah H, Navarini AA, Muehleisen B, Ziv M, Shear NH, Dodiuk-Gad RP
Am J Clin Dermatol 2023 Jul;24(4):557-575. Epub 2023 May 8 doi: 10.1007/s40257-023-00779-3. PMID: 37156992Free PMC Article
Genital Ulcers: Differential Diagnosis and Management.
Roett MA
Am Fam Physician 2020 Mar 15;101(6):355-361. PMID: 32163252
Spanish Guidelines for Diagnosis, Management, Treatment, and Prevention of DRESS Syndrome.
Cabañas R, Ramírez E, Sendagorta E, Alamar R, Barranco R, Blanca-López N, Doña I, Fernández J, Garcia-Nunez I, García-Samaniego J, Lopez-Rico R, Marín-Serrano E, Mérida C, Moya M, Ortega-Rodríguez NR, Rivas Becerra B, Rojas-Perez-Ezquerra P, Sánchez-González MJ, Vega-Cabrera C, Vila-Albelda C, Bellón T
J Investig Allergol Clin Immunol 2020;30(4):229-253. Epub 2020 Jan 14 doi: 10.18176/jiaci.0480. PMID: 31932268

Recent clinical studies

Etiology

Current Perspectives on Severe Drug Eruption.
Zhang J, Lei Z, Xu C, Zhao J, Kang X
Clin Rev Allergy Immunol 2021 Dec;61(3):282-298. Epub 2021 Jul 17 doi: 10.1007/s12016-021-08859-0. PMID: 34273058Free PMC Article
Immune checkpoint inhibitor-related dermatologic adverse events.
Geisler AN, Phillips GS, Barrios DM, Wu J, Leung DYM, Moy AP, Kern JA, Lacouture ME
J Am Acad Dermatol 2020 Nov;83(5):1255-1268. Epub 2020 May 23 doi: 10.1016/j.jaad.2020.03.132. PMID: 32454097Free PMC Article
Fixed Drug Eruptions: An Update, Emphasizing the Potentially Lethal Generalized Bullous Fixed Drug Eruption.
Patel S, John AM, Handler MZ, Schwartz RA
Am J Clin Dermatol 2020 Jun;21(3):393-399. doi: 10.1007/s40257-020-00505-3. PMID: 32002848
Dermatologic Reactions to Immune Checkpoint Inhibitors : Skin Toxicities and Immunotherapy.
Sibaud V
Am J Clin Dermatol 2018 Jun;19(3):345-361. doi: 10.1007/s40257-017-0336-3. PMID: 29256113
Drug-induced Photosensitivity.
Zuba EB, Koronowska S, Osmola-Mańkowska A, Jenerowicz D
Acta Dermatovenerol Croat 2016 Apr;24(1):55-64. PMID: 27149132

Diagnosis

Severe cutaneous adverse reactions.
Hung SI, Mockenhaupt M, Blumenthal KG, Abe R, Ueta M, Ingen-Housz-Oro S, Phillips EJ, Chung WH
Nat Rev Dis Primers 2024 Apr 25;10(1):30. doi: 10.1038/s41572-024-00514-0. PMID: 38664435
Drugs and the skin: A concise review of cutaneous adverse drug reactions.
Del Pozzo-Magaña BR, Liy-Wong C
Br J Clin Pharmacol 2024 Aug;90(8):1838-1855. Epub 2022 Aug 29 doi: 10.1111/bcp.15490. PMID: 35974692
The rash with maculopapules and fever in children.
Muzumdar S, Rothe MJ, Grant-Kels JM
Clin Dermatol 2019 Mar-Apr;37(2):119-128. Epub 2018 Dec 5 doi: 10.1016/j.clindermatol.2018.12.005. PMID: 30981292
The rash with maculopapules and fever in adults.
Muzumdar S, Rothe MJ, Grant-Kels JM
Clin Dermatol 2019 Mar-Apr;37(2):109-118. Epub 2018 Dec 5 doi: 10.1016/j.clindermatol.2018.12.004. PMID: 30981291
Fixed drug eruptions: presentation, diagnosis, and management.
Flowers H, Brodell R, Brents M, Wyatt JP
South Med J 2014 Nov;107(11):724-7. doi: 10.14423/SMJ.0000000000000195. PMID: 25365443

Therapy

Neutrophilic drug reactions.
Coromilas AJ, Gallitano SM
Clin Dermatol 2020 Nov-Dec;38(6):648-659. Epub 2020 Jul 5 doi: 10.1016/j.clindermatol.2020.06.012. PMID: 33341199
Immune checkpoint inhibitor-related dermatologic adverse events.
Geisler AN, Phillips GS, Barrios DM, Wu J, Leung DYM, Moy AP, Kern JA, Lacouture ME
J Am Acad Dermatol 2020 Nov;83(5):1255-1268. Epub 2020 May 23 doi: 10.1016/j.jaad.2020.03.132. PMID: 32454097Free PMC Article
Pityriasis rosea.
Eisman S, Sinclair R
BMJ 2015 Oct 29;351:h5233. doi: 10.1136/bmj.h5233. PMID: 26514823
Acute generalized exanthematous pustulosis (AGEP): A review and update.
Szatkowski J, Schwartz RA
J Am Acad Dermatol 2015 Nov;73(5):843-8. Epub 2015 Sep 6 doi: 10.1016/j.jaad.2015.07.017. PMID: 26354880
Telaprevir-related dermatitis.
Roujeau JC, Mockenhaupt M, Tahan SR, Henshaw J, Martin EC, Harding M, van Baelen B, Bengtsson L, Singhal P, Kauffman RS, Stern RS
JAMA Dermatol 2013 Feb;149(2):152-8. doi: 10.1001/jamadermatol.2013.938. PMID: 23560295

Prognosis

Fixed Drug Eruptions: An Update, Emphasizing the Potentially Lethal Generalized Bullous Fixed Drug Eruption.
Patel S, John AM, Handler MZ, Schwartz RA
Am J Clin Dermatol 2020 Jun;21(3):393-399. doi: 10.1007/s40257-020-00505-3. PMID: 32002848
The rash with maculopapules and fever in children.
Muzumdar S, Rothe MJ, Grant-Kels JM
Clin Dermatol 2019 Mar-Apr;37(2):119-128. Epub 2018 Dec 5 doi: 10.1016/j.clindermatol.2018.12.005. PMID: 30981292
The rash with maculopapules and fever in adults.
Muzumdar S, Rothe MJ, Grant-Kels JM
Clin Dermatol 2019 Mar-Apr;37(2):109-118. Epub 2018 Dec 5 doi: 10.1016/j.clindermatol.2018.12.004. PMID: 30981291
Dermatologic Reactions to Immune Checkpoint Inhibitors : Skin Toxicities and Immunotherapy.
Sibaud V
Am J Clin Dermatol 2018 Jun;19(3):345-361. doi: 10.1007/s40257-017-0336-3. PMID: 29256113
The DRESS syndrome: a literature review.
Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L, Roujeau JC
Am J Med 2011 Jul;124(7):588-97. Epub 2011 May 17 doi: 10.1016/j.amjmed.2011.01.017. PMID: 21592453

Clinical prediction guides

Cephalosporin Allergy: Current Understanding and Future Challenges.
Khan DA, Banerji A, Bernstein JA, Bilgicer B, Blumenthal K, Castells M, Ein D, Lang DM, Phillips E
J Allergy Clin Immunol Pract 2019 Sep-Oct;7(7):2105-2114. doi: 10.1016/j.jaip.2019.06.001. PMID: 31495420Free PMC Article
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article
Dermatologic Reactions to Immune Checkpoint Inhibitors : Skin Toxicities and Immunotherapy.
Sibaud V
Am J Clin Dermatol 2018 Jun;19(3):345-361. doi: 10.1007/s40257-017-0336-3. PMID: 29256113
Cutaneous adverse effects of targeted therapies: Part I: Inhibitors of the cellular membrane.
Macdonald JB, Macdonald B, Golitz LE, LoRusso P, Sekulic A
J Am Acad Dermatol 2015 Feb;72(2):203-18; quiz 219-20. doi: 10.1016/j.jaad.2014.07.032. PMID: 25592338
The DRESS syndrome: a literature review.
Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L, Roujeau JC
Am J Med 2011 Jul;124(7):588-97. Epub 2011 May 17 doi: 10.1016/j.amjmed.2011.01.017. PMID: 21592453

Recent systematic reviews

Paradoxical eruptions to targeted therapies in dermatology: A systematic review and analysis.
Murphy MJ, Cohen JM, Vesely MD, Damsky W
J Am Acad Dermatol 2022 May;86(5):1080-1091. Epub 2020 Dec 8 doi: 10.1016/j.jaad.2020.12.010. PMID: 33307146
Perioral dermatitis: Diagnosis, proposed etiologies, and management.
Searle T, Ali FR, Al-Niaimi F
J Cosmet Dermatol 2021 Dec;20(12):3839-3848. Epub 2021 Mar 16 doi: 10.1111/jocd.14060. PMID: 33751778
Dermatological adverse events with taxane chemotherapy.
Sibaud V, Lebœuf NR, Roche H, Belum VR, Gladieff L, Deslandres M, Montastruc M, Eche A, Vigarios E, Dalenc F, Lacouture ME
Eur J Dermatol 2016 Oct 1;26(5):427-443. doi: 10.1684/ejd.2016.2833. PMID: 27550571Free PMC Article
Rituximab-induced serum sickness: A systematic review.
Karmacharya P, Poudel DR, Pathak R, Donato AA, Ghimire S, Giri S, Aryal MR, Bingham CO 3rd
Semin Arthritis Rheum 2015 Dec;45(3):334-40. Epub 2015 Jun 26 doi: 10.1016/j.semarthrit.2015.06.014. PMID: 26199061
Mycoplasma pneumoniae-induced rash and mucositis as a syndrome distinct from Stevens-Johnson syndrome and erythema multiforme: a systematic review.
Canavan TN, Mathes EF, Frieden I, Shinkai K
J Am Acad Dermatol 2015 Feb;72(2):239-45. doi: 10.1016/j.jaad.2014.06.026. PMID: 25592340

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